Abstract: This paper constructs an integrated research model of firms’ capacity mechanism under the background of open innovation by applying Lichtenthaler’s capability-based framework for open innovation. Through a method of literature review, this research introduces three main capacity construction types of the high-tec SMEs including: R&D oriented, net cooperation oriented and absorption desorption oriented and identifies biopharmaceutical SMEs which are on the front line of innovation, possess typical capacity characteristics as absorption desorption oriented. Through a method of dynamic simulation, this paper studies and compares biopharmaceutical SMEs’s performances under different environmental turbulences during continuous innovation processes. Research finds out that biopharmaceutical SMEs have the best performances under a turbulent environment.