Abstract: Abstract: From the perspective of input - output, this paper examines the regional science and technology innovation level (in Zhejiang province as an example) and analyzes its macro influencing factors, empirically discusses the actor of government supports and high-tech industry’s own development in improving technology innovation efficiency. At first, this paper uses the nonparametric estimation method (DEA - Malmquist index method) to assess the efficiency of the current scientific and technological innovation in Zhejiang province, and then uses the method of parameter estimation (stochastic frontier production function method, SFA), which is more stable to analyze the macro factors later. After controlling for the environmental factors, such as regional economic development, trade openness and financial development and industrial structure, we found that government supports for the regional technological innovation efficiency exists significant negative effects, while industry development shows a significantly positive role. In this paper, the instrumental variable method is adopted to reduce the endogenous and using variance correct technology to eliminate the influence of heteroscedasticity, and the results remain robust.